Friday, April 26, 2013

Legal issues surround Boston suspect's questioning

WASHINGTON (AP) ? The hospital-room questioning of the surviving suspect in the Boston Marathon bombings is generating concern about whether he should have been interrogated without first being told of his constitutional rights to silence and a lawyer ? and, conversely, whether federal agents actually should have had more time with him before he was read his rights.

Dzhokhar Tsarnaev faced 16 hours of questioning before he was advised of his Miranda rights, and investigators say he told them of his role in the two bombings near the Boston Marathon finish line on April 15. He explained that he and his brother, Tamerlan, were angry about the U.S. wars in Afghanistan and Iraq and the killing of Muslims there, according to two U.S. officials who spoke on condition of anonymity because they weren't authorized to discuss the case with reporters.

He also described a spur-of-the-moment plan that the brothers hatched to drive to New York and set off their remaining explosives there, New York City officials said Thursday.

In Boston, federal agents invoked an exception to the Miranda warnings that allows for questioning when public safety may be threatened. But they knew their time with Tsarnaev in the absence of a lawyer would be limited.

On Sunday, prosecutors filed a criminal complaint charging Tsarnaev with a role in the bombings. That action led directly to the improvised court hearing in the hospital the following morning at which U.S. Magistrate Judge Marianne Bowler told Tsarnaev he did not have to answer questions and could have a lawyer.

And he apparently did stop, though other cases in recent years suggest that silence won't necessarily last.

Could that first hearing on Monday have been delayed?

The hearing is supposed to take place "without unnecessary delay," according to the federal rules, sometimes within a matter of hours.

The rules governing such hearings, known as an initial appearance, require the judge to tell a defendant of his rights, Justice Department spokesman Dean Boyd said. "The prosecutors and FBI agents in Boston were advised of the scheduled initial appearance in advance of its occurrence."

Civil liberties advocates have said a suspect should rarely be questioned without a lawyer and without being told he doesn't have to respond.

"Miranda rights are an incredibly important civil liberties safeguard," said Hina Shamsi of the American Civil Liberties Union. "The public safety exception must be read narrowly, as it has been by the courts."

But California Democratic Rep. Adam Schiff, a former federal prosecutor, said he has questions about how the court proceeding came about.

"I would have thought the public safety exception would have allowed more time for the questioning of the suspect prior to the arraignment and/or advising of rights," Schiff said.

A fellow Democrat, Sen. Carl Levin of Michigan, agreed that some questions remain about when the judge arrived and whether she interrupted questioning. But, Levin said, " we do know there was 16 hours of questioning and that they got very detailed information."

Withholding a criminal suspect's Miranda rights becomes a legal issue only if authorities try to use what they learned during the questioning.

In fact, prosecutors probably will want to introduce Tsarnaev's confession as evidence against him.

"Prosecutors always prefer to have a confession," said Tamar Birckhead, a former federal defender in Boston who now teaches law at the University of North Carolina. She predicted there would be a protracted legal battle over Tsarnaev's statements, if his case comes to trial and prosecutors say they intend to use them.

But other legal experts said any controversy over those early statements should not obscure the rest of the government's case.

"When you read the affidavit, it lays out the evidence the FBI gathered wholly apart from any statements he made to law enforcement. Based on my experience, that's a pretty strong case, even without statements made by the defendant to law enforcement directly," said former federal prosecutor Juliet Sorensen, a Northwestern University law professor.

Tsarnaev apparently stopped talking to investigators once Bowler appointed the Federal Public Defender's office in Boston to represent him, said a U.S. law enforcement official and three congressional officials representing both political parties. The law enforcement official spoke on condition of anonymity because the official wasn't authorized to talk about the case with reporters. The congressional officials spoke on condition of anonymity because their information came from a confidential FBI briefing.

But that may not be final. Umar Farouk Abdulmutallab of Nigeria, convicted of trying to blow up a packed jetliner using a bomb sewn into his underwear on Christmas Day 2009, also initially answered investigators' questions and then clammed up once he was read his rights, only to start cooperating again.

"This notion that they 'lawyer up' and that's the end of getting any information is just not true," said Miami defense lawyer Neal Sonnett.

David Cole, a Georgetown University law professor, said lawyers sometimes encourage their clients to cooperate. "The government generally has a lot of evidence against the individual. The criminal sentences are harsh and the likelihood of conviction is high. Defense counsel, seeing that, will often understand that cooperating is in his client's best interests," Cole said.

Source: http://news.yahoo.com/legal-issues-surround-boston-suspects-questioning-213211849.html

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Monday, April 22, 2013

David Ortiz forgiven by FCC for expletive Boston will never forget (+video)

David Ortiz used an expletive in his defiant (and televised) speech Saturday before the first Red Sox home game since the Boston Marathon bombing. The FCC has already weighed in. ?

By Mark Sappenfield,?Staff writer / April 21, 2013

Boston Red Sox slugger David Ortiz pumps his fist in front of an American flag and a line of Boston Marathon volunteers after addressing the crowd before a baseball game between the Red Sox and the Kansas City Royals in Boston Saturday.

Michael Dwyer/AP

Enlarge

On a day when the city of Boston came to Fenway Park for its collective exhale, honoring the governor and mayor and law enforcement officials who have served with such distinction during the past week of terror, it was the one indelible moment. The crowd roared louder than it had all afternoon. People on the Internet are already making T-shirts.

Skip to next paragraph Mark Sappenfield

Staff writer

Mark is deputy national news editor for the Monitor.

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It was, in five words, the encapsulation of a city's defiance ? bowed, but never broken. Not even close.

It also happened to be NSFW (not safe for work). Or children. Or anyone in Mr. Rogers' neighborhood.?

It was the declaration by legendary Red Sox slugger David Ortiz in pregame ceremonies Saturday, which were broadcast nationwide.

"This is our f------ city, and nobody's going to dictate our freedom."

In recent years, the Federal Communications Commission has taken to calling such incidents "fleeting expletives," and has grown increasingly grumpy about them. For years, the major television networks behaved themselves, pushing any potentially objectionable content past 10 p.m., when kids who might ask "Mommy, what is cow s---?" had already gone to bed.

Then came reality TV star Nicole Richie, who said live during the December 2003 Billboard awards show on Fox, "Have you ever tried to get cow s--- out of a Prada purse? It's not so f------ simple."

Or U2 singer Bono, who said during NBC's broadcast of the Golden Globes awards show earlier that year: "f------ brilliant."

For these incidents and others, the FCC responded by fining networks more than $1 million. Though the fines were later overturned by the Supreme Court, the point was made. There was a new sheriff in town. The networks have responded, running awards shows on several-second delays so they can beep out any offenders.

But on Saturday, no one beeped out Mr. Ortiz ? known to Bostonians as "Big Papi." And within the hour, FCC chairman Julius Genachowski had taken to Twitter to say that was just fine.

"David Ortiz spoke from the heart at today's Red Sox game. I stand with Big Papi and the people of Boston - Julius," the tweet read.

Mark Townsend of Yahoo's Big League Stew blog added his 2 cents: "There's a right time, and there's a wrong time to be too emotional. Today was definitely the right time (and yes, I know there were children in the building)."

Commenters largely agreed. One, named Hawk, summed up the sentiment this way: "I'm gonna go ahead and vote Papi for MVP. Most Valuable Phrasing!" Another, named Ted, added: "When Papi said that, I got goosebumps."

On a joyous day to end a tragic week that Boston ? and the world ? will not soon forget, Ortiz's expletive was anything but fleeting, it seems.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/GMMhaV6s3rE/David-Ortiz-forgiven-by-FCC-for-expletive-Boston-will-never-forget-video

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Analysis: BP's legal gamble may trim spill bill by billions

By Kathy Finn and Braden Reddall

NEW ORLEANS/SAN FRANCISCO (Reuters) - BP Plc's attempt to get a U.S. federal court to pin at least a sizeable amount of the blame for the Deepwater Horizon disaster on other companies may have saved it billions of dollars.

After failing to settle claims from the 2010 Gulf of Mexico spill through negotiations, the British oil company opted in February to go to trial with plaintiffs ranging from small businesses to the U.S. government over the damages it will face.

The decision rests with U.S. District Court Judge Carl Barbier, who could issue findings on blame and the level of negligence as early as July.

Legal experts say BP appeared to succeed in shifting some of the blame for the disaster to rig owner Transocean Ltd and cement provider Halliburton Co. In doing so, it may have shaved a slice off a liability that could stretch into the tens of billions of dollars.

BP "put their faith in the hands of the court," said Blaine LeCesne, a tort law professor at Loyola University in New Orleans who has followed the trial closely. "It looks like that might have paid off."

Of course, if Barbier determines that BP was grossly negligent then it could more than offset anything it has saved by getting the rap for the disaster shared more broadly.

LeCesne, and two other legal experts who followed the trial but spoke privately on the matter, believed BP had some success in offloading blame for the worst U.S. offshore spill, which was caused by a blowout on the Deepwater Horizon rig that killed 11 people exactly three years ago on Saturday.

During the trial last Wednesday, Transocean may have taken a hit from BP's final witness, Andrew Mitchell, a 40-year veteran of the offshore oil industry and now an International Safety Management Code consultant.

Mitchell described the rig captain's response to the crisis as "completely inadequate." That came on top of Transocean's previous admission that its employees misinterpreted a crucial pressure test on the well and evidence that a dead battery in the blow-out preventer kept the device from closing the well hole.

Transocean declined to comment on specifics of the trial, but said it remained confident in the case it presented.

Halliburton also took some blows. Last month the company belatedly introduced cement samples into evidence. Then this month, Halliburton produced documents, including test results BP lawyer Mike Brock said he would have liked to have had while Halliburton witnesses were still on the stand.

Another document included an email in which a Halliburton executive said their company was one of the "contributing parties" responsible for ensuring a sound cement job.

"It's very troubling the way Halliburton has handled this entire matter," Judge Barbier said of the documents, adding that he was considering whether to impose sanctions in response.

Halliburton did not respond to a request for comment.

Testimony in the first phase of the trial ended April 17. With an estimated 70 million pages of evidence to weigh, the parties have 80 days to file legal briefs as Barbier considers blame and negligence in the non-jury trial.

Phase two would determine exactly how much oil spilled so damages can be assessed, a process due to start in September. Legal sources say it is possible Barbier could delay announcing his phase-one trial conclusions until after the next phase, so total fines and penalties may not be known until 2014.

LeCesne expects BP could shoulder about 70 percent of the blame and that Halliburton might bear a heavier share of the rest due to testimony regarding the failure of its cement mixture in attempts to plug the well.

"I'd say Halliburton is likely to have an equal or higher percentage attributed to it than Transocean," LeCesne said.

BP spokesman Geoff Morrell said the evidence presented at the trial showed BP was not grossly negligent and the accident was the result of "multiple causes, involving multiple parties."

HISTORY LESSON

BP has been determined from the start of the oil spill to avoid the decades of litigation that Exxon Mobil Corp endured after the 1989 Valdez accident in Alaska. But the complexity of BP's case meant a last-minute deal in February was elusive, so it landed in court.

BP has already allocated $42 billion to cover clean-up, fines and other costs. A gross negligence finding by Barbier could add billions to the civil penalties and expose BP to punitive damages claims. BP's liability under the U.S. Clean Water Act alone could reach $17.5 billion if BP is found grossly negligent. Billions more could be piled on in economic damage claims from Gulf Coast states, while a third set of claims, for natural resource damage, have not yet been filed.

Just in the past few days, the states of Mississippi and Florida have filed suit against BP over the spill. Louisiana and Alabama have been parties to the civil litigation for two years.

While some observers think the results of the trial's first phase will prompt a settlement of many remaining claims, LeCesne believes the parties will continue to duke it out in court. He also thinks even if BP did reduce its share of the blame during the trial, a very costly ruling against BP is in the cards.

"It's by no means a certainty, but I think it's more likely than not there will be a finding of gross negligence," he said.

John Levy, a maritime and complex litigation expert at Montgomery, McCracken, Walker & Rhoads, said all the money at stake is what made the Deepwater Horizon case special among maritime cases.

"On smaller cases, people will just work it out," he said. "Here, you're talking about numbers that end with the word billion. It's worth fighting over."

The case is In re: Oil Spill by the Oil Rig "Deepwater Horizon" in the Gulf of Mexico, on April 20, 2010, U.S. District Court, Eastern District of Louisiana, No. 10-md-02179.

(Reporting by Kathy Finn in New Orleans and Braden Reddall in San Francisco; Editing by Patricia Kranz and Matt Driskill)

Source: http://news.yahoo.com/analysis-bps-legal-gamble-may-trim-spill-bill-052009507--finance.html

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Pinterest Business Boards > Free Online Marketing Report - Free ...

Free Marketing report ?Pinterest Business Boards? looks at What Is Pinning and Repinning?, Following, Adding comments, Using Pinterest For Business, Share Your Business Philosophy through Images, Make Your Pins Stand Out, Connect with Your Customers and Potential Customers and Driving Traffic to Your Site with Pinterest. Includes give away rights. Click ?Pinterest Business Boards? to download or view this free Pinterest report. Note > pdf, ecovers zip file available Here.

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Sunday, April 21, 2013

Jonas Brothers Glad 'People Are Actually Showing Up' After Reunion

After three-year hiatus, the JoBros tell MTV News they've made their 'best record yet.'
By Jocelyn Vena, with reporting by Christina Garibaldi


Jonas Brothers: Live From MTV
Photo: MTV News

Source: http://www.mtv.com/news/articles/1706095/jonas-brothers-reunion-success.jhtml

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This Week's Most Popular Posts: April 12th to 19th

This week we learned what to say to our kids, fought back against the cable companies, busted some stress, and escaped the "cult of busy." Here's a look back.

S

10 Things to Stop Saying to Your Kids (and What to Say Instead)

Current research shows that some of the most commonly used and seemingly positive phrases we use with kids are actually quite destructive. Despite our good intentions, these statements teach children to stop trusting their internal guidance system, to become deceptive, to do as little as possible, and to give up when things get hard.

S

Top 10 Instant Stress Busters

Beating chronic stress is a long-term effort, and we've shared a lot of ways to deal with it?but what if you're overcome with stress right now and just want to calm down? Here are ten ways you can bust through stress and get on with your day.

S

Five Best Small Form Factor PC Cases

If you're building an HTPC, a small workstation, or you just don't want your rig to take up tons of space under or on top of your desk, you need a smaller PC case. Something that fits the important stuff, but doesn't waste a lot of space on expansion bays or components you may not need. This week we're going to take a look at five of the best for the job.

S

Cable Companies Can Now Force You to Rent Set-Top Boxes. Here Are Your Alternatives.

For many customers, cable may be getting even more expensive. A new FCC ruling lets cable providers require customers to rent set-top boxes for their basic tiers (including local stations). With HD boxes running around $10 a month for each TV and using more power than the fridge, this might be the straw the breaks the cable subscriber's back. Here are your other options.

Add Some Extra Storage to Your Home This Weekend

Not all homes are blessed with endless closet space, so you often need to sell your unwanted crap or find a way to store it. This weekend we're assuming you're a pack rat rather than a minimalist and have a number of DIY projects to help you stash more stuff.

S

How to Escape the Cult of "Busy"

People who often say they're "too busy" or "crazy busy" sound like buzzing busy signals. And when you start sounding like an appliance, it makes it hard to connect with you.

S

Four People, One Salary: How They Spend and Save on $60,000

There's a reason why guests look in the medicine cabinet. (Not you, of course.) It's human nature to want to get a peek at how other people live. It helps us to feel as if our mistakes aren't all that unusual?that our best efforts are good enough to keep up with the crowd because everyone else makes them too. Today, we'll be engaging in another kind of look-see...into other people's budgets.

S

What Can a Smart Thermostat Do that Mine Can?t Already Do?

Dear Lifehacker, I've been hearing a lot about "smart" thermostats like the Nest. I've heard they're programmable and can save me money on energy, but aren't all thermostats programmable? What's so special about smart thermostats? Should I buy one?

Mount Your Router to the Wall for Better Wi-Fi Reception

If you struggle with bad Wi-Fi reception, or just don't have a good table to set your router, you could mount it high on your wall with some inexpensive hangers.

S

The 20/4/10 Rule Keeps Your Finances Under Control When Buying a New Car

Overextending your bank account when buying a new car can leave you in a lurch if a financial crisis strikes before it's paid off. Be sure to use the simple 20/4/10 rule to avoid taking on a bigger car loan than you can comfortably absorb within your budget.

S

Your Quarterly Jailbreak App Roundup, April 2013

Every day, tons of great little jailbreak tweaks and apps for the iPhone come out that we don't talk about. These can be as minor as a tweak that allows you to change how the music app works to full blown apps that let you record your screen. With that in mind, here are a few of our favorites from the last few months.

Combine a PS3, Xbox 360, and Wii U into a Single Frankensystem

Swapping wires and switching inputs on your TV to use different game systems is a pain. Ben Heck was sick of it, so he hacked-together a custom system that combines a PS3, Xbox 360, and Wii U in one box.

S

How to Build Your First Home Theater From Nothing

Setting up a proper home theater doesn't have to be terribly expensive or complicated. If you're still watching TV on a tiny screen and crappy speakers, it's time to upgrade. Here's how to set up your first real home theater.

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/__p23sd7vFA/this-weeks-most-popular-posts-april-12th-to-19th-476493981

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Saturday, April 20, 2013

PFT: The 12 most intriguing NFL games of 2013

Denver Broncos v New England PatriotsGetty Images

Schedule-release day! It?s one of the sneaky-good pro football events of the year.

When I ponder the schedule, I look for clues for where a team may soar, wobble or plummet. The following 12 games all look like they could teach us something important about the teams on the field. I generally focused on games earlier in the season than later; it?s tough enough to speculate on how a team could play in September, but projecting a team?s late-December form is even more challenging.

Here are 12 games that particularly interest me:

49ers at Seahawks (Sept. 15) ? Appointment viewing. End of story. To paraphrase Mike Mayock, put on the tape of Russell Wilson and Colin Kaepernick from the postseason. Just do it. I?ll be watching for many reasons, but mainly to see whether either West power looks significantly better than the other.

Giants at Panthers (Sept. 22) ??This is the sort of game the upstart Panthers will win if they are going anywhere. And it?s precisely the sort of game Tom Coughlin?s team pulls out when in top form.

Lions at Packers (Oct. 6) ??The Lions have the offensive might to give any defense fits and were a legitimate playoff entrant two years ago. Can they bounce back after a disappointing 2012 performance? This looks like a big class test for them.

Seahawks at Colts (Oct. 6) ??I love out-of-conference battles between two talented clubs. A win for either team is a real nice item to have on the r?sum?. The Seahawks are capable of winning in a tough venue, but the Colts were very, very tough at home a season go.

Redskins at Cowboys (Oct. 13) ? Dallas did not fare well in its first two tries against Robert Griffin III and Alfred Morris.

Eagles at Buccaneers (Oct. 13) ? The Buccaneers had a strong run defense a season ago, and the Eagles? Chip Kelly-designed offense is talent- and potential-laden. This should be fun.

Ravens at Steelers (Oct. 20) ? For years, this has been one of the NFL?s compelling rivalries, and doesn?t figure to change in 2013, not with Baltimore the depending champion and Pittsburgh trying to regain its footing among the AFC elite.?The Steelers won in Baltimore last season, one of the highlights of a disappointing campaign.

Dolphins at Patriots (Oct. 27) ??Last year, the Bills were the chic pick to make a run at New England?s AFC East supremacy. This year, the Dolphins are the East sleeper. Can Miami live up to the hype? The Dolphins are likely to be underdogs in Foxborough; if that?s the case, how the Dolphins play may trump whether they win or lose, in my view. If the Dolphins give a strong Patriots team a game, it?s a good sign for Miami.

Colts at Texans (Nov. 3) ??For the Texans, getting to the playoffs doesn?t constitute great success anymore. For the Colts, a step backwards after a surprising 2012 season would be a big disappointment.

Chiefs at Broncos (Nov. 17) ??Who?s going to push Denver in the AFC West? Kansas City might have the best shot. Let?s see how the Chiefs measure up.

Saints at Falcons (Nov. 21) ? A weakened Saints team managed to split the season series in 2012. Now, Sean Payton is back, and New Orleans could be ready to seriously contend once again in the NFC South. With both teams again likely to field strong offenses, the play of the defenses could tell the tale.

Broncos at Patriots (Nov. 24) ? Including the playoffs, this is the fourth meeting between the teams in the last three seasons ? and Denver has had no good answers for New England?s powerful offense. The Patriots have won all three meetings, averaging 39 points in the victories. The Broncos have the ability to be strong contenders, but their problems with the Patriots can?t be overlooked.

Source: http://profootballtalk.nbcsports.com/2013/04/18/twelve-intriguing-regular-season-games/related/

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Friday, April 19, 2013

Topical use of arthritis drug provides relief for dry eye disease, study suggests

Apr. 18, 2013 ? Dry eye disease (DED) is a common condition that causes discomfort, visual disturbance and potentially damaging ocular surface inflammation that greatly impacts a person's quality of life. An estimated nine million people in the United State alone suffer from significant DED; millions more may have milder forms or experience discomfort when exposed to low humidity or contact lens use. DED, the most common reason people visit ophthalmologists, is estimated to cost $55 billion in annual direct and indirect costs to society in the nation alone.

In a new study, researchers from the Massachusetts Eye and Ear, Harvard Medical School, and Brigham and Women's hospital show that topical anakinra (Kineret; Amgen Inc.), a recombinant version of human IL-1Ra approved for treatment of rheumatoid arthritis, significantly reduced dry eye symptoms. Topical use of a protein-based biologic agent in treatment of DED is unprecedented and may herald a new era of highly targeted topical molecular treatments for ocular surface disease. The results of this clinical trial are described online first in JAMA Ophthalmology.

"We began looking at the possible therapeutic effects of IL-1Ra over 10 years ago in my laboratory," said Reza Dana, M.D., MSc., M.PH., senior author. "This clinical trial was a significant milestone in our research. The results clearly show us not only that we can possibly help the millions of people affected by dry eye disease worldwide, but that biologics such as this have the potential to provide targeted therapies for other ocular ailments, as well."

Early studies have shown that DED is associated with significant overexpression of inflammatory cytokines, including interleukin 1 (IL-1), in the eye. However the options to treat the inflammatory component of DED have been limited and some of these involved adverse effects. Anti-inflammatory medications such as tetracycline derivatives, topical corticosteroids, and cyclosporine A that have been successfully used in the treatment of DED downregulate the production of IL-1 and upregulate the production of IL-1 receptor antagonist (IL-1Ra) at the ocular surface. The IL-1Ra suppresses IL-1-mediated inflammation by completely inhibiting the binding of IL-1a and IL-1b to IL-1 receptor I. Topical IL-1Ra has been successfully used to treat experimental rodent models of corneal transplant rejection, dry eye disease, allergic conjunctivitis and alkali burn-associated ocular inflammation.

The researchers performed a randomized, double-masked clinical trial designed to assess the safety of efficacy of topical IL-1Ra in patients with DED. Seventy-five participants in the 16-week study were randomly allocated in the 2:2:1 ratio to receive eye lubricant (artificial tear), 2.5% of anakinra or 5% of anakinra. Patients found the anakinra was well tolerated and was significantly more effective than the eye lubricant in improving the signs and symptoms of DED. Anakinra at 2.5% was four times more likely than the eye lubricant to bilaterally eliminate corneal staining, a clinical measurement of ocular surface disease. Topical anakinra also significantly reduced dry eye symptoms six times more effectively than the eye lubricant, which is capable of independently improving the signs of DED. Moreover, termination of anakinra (but not the lubricant) application at week 12 lead to a clear trend toward increased symptoms between weeks 12 and 16, confirming the therapeutic effect of the drug.

"We have never seen results such as this before in a trial to treat dry eye disease. We possibly have found a safe, well tolerated eye drop that can treat the underlying cause of dry eye rather than just temporarily mask the symptoms. We are excited about the positive results we saw in the data and with our patients who found relief in their symptoms and were able to return to some of their normal daily activities," Dr. Dana said.

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Story Source:

The above story is reprinted from materials provided by Massachusetts Eye and Ear Infirmary, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Francisco Amparo et al. Topical Interleukin 1 Receptor Antagonist for Treatment of Dry Eye DiseaseA Randomized Clinical Trial. JAMA Ophthalmology, 2013 DOI: 10.1001/jamaophthalmol.2013.195

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/Q2fhY0aD15k/130418162310.htm

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Ryan Reynolds Hunts The Dead In New 'R.I.P.D.' Trailer

The supernatural buddy cop film follows Ryan Reynolds and Jeff Bridges as they police the souls that skirt the afterlife.
By Brett White


Jeff Bridges and Ryan Reynolds in "R.I.P.D."
Photo: Universal Pictures

Source: http://www.mtv.com/news/articles/1705929/ryan-reynolds-ripd.jhtml

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Child's counting comprehension may depend on objects counted, study shows

Apr. 18, 2013 ? Concrete objects -- such as toys, tiles and blocks -- that students can touch and move around, called manipulatives, have been used to teach basic math skills since the 1980s. Use of manipulatives is based on the long-held belief that young children's thinking is strictly concrete in nature, so concrete objects are assumed to help them learn math concepts.

However, new research from the University of Notre Dame suggests that not all manipulatives are equal. The types of manipulatives may make a difference in how effectively a child learns basic counting and other basic math concepts. The study will be published in the May edition of Child Development.

University of Notre Dame Associate Professor of Psychology Nicole McNeil, who researches how children think, learn and solve problems in mathematics, together with Notre Dame graduate student Lori Petersen found that use of certain objects have mixed results with preschoolers, particularly if those objects are rich in perceptual detail (bright and shiny).

Objects that are brightly colored, unusually textured or highly dimensional may capture children's attention and help children stay focused on the given task. However, the researchers found that when children already were familiar with the objects, then these perceptually detailed objects actually hindered performance on counting tasks because they require dual representation -- they must be represented both as objects themselves and as the abstract mathematical concept they are intended to represent. When children already have established knowledge of the objects, this increased attention often is directed to the objects and their known purpose rather than to the mathematical task at hand. Conversely, when children didn't have established knowledge of the objects, perceptual richness helped performance.

"These findings suggest that it is easier for children to use objects in mathematical tasks when those objects have maximum 'bling' and minimum recognizability," McNeil said.

"More generally, these findings suggest that teachers may benefit from taking children's previous knowledge into account when deciding which materials to bring into their classrooms."

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Story Source:

The above story is reprinted from materials provided by University of Notre Dame.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Lori A. Petersen, Nicole M. McNeil. Effects of Perceptually Rich Manipulatives on Preschoolers' Counting Performance: Established Knowledge Counts. Child Development, 2012; DOI: 10.1111/cdev.12028

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/mind_brain/child_development/~3/agvW-MxOb8U/130418154405.htm

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Thursday, April 18, 2013

Palestinians seeking statehood look to high-tech

In this Saturday, April 6, 2013 photo, a Palestinian programmer attends a Ramallah Startup Weekend workshop in the West Bank city of Ramallah. The Palestinians are turning to their fledgling high-tech sector as they try to lay the groundwork for an independent state. Local entrepreneurs say their unique circumstances, including years of experience coping with Israeli travel restrictions, have fostered a creative spirit conducive to the entrepreneurial high-tech world.((AP Photo/Majdi Mohammed)

In this Saturday, April 6, 2013 photo, a Palestinian programmer attends a Ramallah Startup Weekend workshop in the West Bank city of Ramallah. The Palestinians are turning to their fledgling high-tech sector as they try to lay the groundwork for an independent state. Local entrepreneurs say their unique circumstances, including years of experience coping with Israeli travel restrictions, have fostered a creative spirit conducive to the entrepreneurial high-tech world.((AP Photo/Majdi Mohammed)

In this Friday, April 5, 2013 photo, Palestinian programmers attend a Ramallah Startup Weekend workshop in the West Bank city of Ramallah. The Palestinians are turning to their fledgling high-tech sector as they try to lay the groundwork for an independent state. Local entrepreneurs say their unique circumstances, including years of experience coping with Israeli travel restrictions, have fostered a creative spirit conducive to the entrepreneurial high-tech world.((AP Photo/Majdi Mohammed)

In this Saturday, April 6, 2013 photo, a Palestinian programmer attends a Ramallah Startup Weekend workshop in the West Bank city of Ramallah. The Palestinians are turning to their fledgling high-tech sector as they try to lay the groundwork for an independent state. Local entrepreneurs say their unique circumstances, including years of experience coping with Israeli travel restrictions, have fostered a creative spirit conducive to the entrepreneurial high-tech world.((AP Photo/Majdi Mohammed)

In this Friday, April 5, 2013 photo, Palestinians programmers attend a Ramallah Startup Weekend workshop in the West Bank city of Ramallah. The Palestinians are turning to their fledgling high-tech sector as they try to lay the groundwork for an independent state. Local entrepreneurs say their unique circumstances, including years of experience coping with Israeli travel restrictions, have fostered a creative spirit conducive to the entrepreneurial high-tech world.(AP Photo/Majdi Mohammed)

(AP) ? Palestinians are turning to their fledgling high-tech sector as they lay the groundwork for a future state, saying the unique hardships of life in the West Bank have fostered a creative spirit conducive to the world of startups.

Dozens of high-tech hopefuls recently competed for the honor of having the best business idea at the West Bank's premier startup conference. Just a few kilometers (miles) away, Palestinian youths clashed with Israeli security forces at a military checkpoint on the outskirts of Jerusalem.

Despite the unrest nearby, the scene at the conference was more reminiscent of Silicon Valley. Casually dressed young men and women in headscarves and skinny jeans gathered in groups to discuss ideas for innovative products and services.

Palestinians charge that Israel has restricted their economy with checkpoints and other limitations, citing security needs, but ideas don't stop at military checkpoints and border crossings, said George Khadder, one of the conference's organizers and chief marketing officer at the startup company, Yafa Energy. "All you need is a brain, a computer and an Internet connection."

Organizers said the goal was to encourage the entrepreneurial spirit and lay a foundation for a thriving high-tech industry. In particular, they want to move beyond traditional low-margin outsourcing work and create Palestinian companies with original ideas and products.

"Outsourcing is important. It will create a platform for hiring employees who might at some point leave the company and start their own firms, but it cannot be the strategic advantage of Palestine," said Khadder, co-founder of Peeks, a grassroots organization that promotes technology and entrepreneurship and got its name from the phrase "Palestinian geeks."

"What Palestinians need in the tech sector ... is to create their own intellectual property, their own products and services that can be sold over the Internet," Khadder said.

The Palestinians, who want to see the West Bank and east Jerusalem as part of a future independent state, think they are uniquely positioned to make a push into technology. Palestinian society puts a premium on higher education and Israeli travel restrictions that have historically hindered the West Bank economy have also fostered Internet use.

Palestinians have one of the highest rates of Internet use in the Arab world. A 2012 study on social media use in the Arab world, conducted by the Dubai School of Government for instance, ranked Palestinians third in Facebook use after Lebanon and Kuwait.

While the Palestinian tech industry is still in its infancy, it has been heavily influenced by Israel, a global technology powerhouse.

The Palestinians import about $22 million in information-technology services from Israel, according to Sabri Saidam, a tech adviser to Palestinian President Mahmoud Abbas. And dozens of Palestinian firms perform outsourcing work for Israeli-based companies, making technology a rare area of cooperation between the sides.

During the 54-hour technology marathon earlier this month, young Web developers, designers, computer science students and entrepreneurs pitched products related to job recruiting and music to a university notes-sharing system.

There was an idea for a system that would remotely connect psychologists to people with low mobility, like women in the Arab Gulf. Another participant proposed a game starring a character ? donning a Palestinian kaffiyeh, or checkered headdress, around his neck ? who jumps over Israel's West Bank separation barrier. The goal of the game is to reach Jerusalem, which is off-limits for most Palestinians and requires a special Israeli permit.

For all, the dream is to replicate the success of Yamsafer and Souktel, successful Palestinian startups that have raised $1 million in venture capital. Both have been financed by Sadara Ventures, the first information technology-focused venture capital firm in the Palestinian territories.

Yamsafer, co-founded by chief executive Faris Zaher, is a hotel and events booking website that targets Arab-speaking clients and offers competitive prices in Middle East destinations.

Souktel is a mobile phone-based service connecting job seekers with employers. Started in 2006 by Mohammed al-Kilany, the company has expanded to more than 15 countries.

"The first step of an entrepreneur's life is to resist people's denial," said al-Kilany, 30, who worked as a waiter to help finance his venture. "People look at you as if you're crazy and doing something crazy."

But participants said the road to building a viable startup is riddled with risks: Legal barriers, an uncertain tax climate, outdated intellectual property rights laws and bureaucracy. Lurking in the background is the conflict with Israel and cultural norms in Palestinian society that frown upon risk-taking in favor of more traditional jobs like law, medicine or the civil service.

Al-Kilany, the founder of Souktel, said the tight-knit Palestinian family life, however, can be a benefit. He said his father once sold the family car so he could finish his college degree.

"This is the Arab culture," he said. "My mom said, 'This is your education. This is the key to your future.'"

According to official Palestinian government statistics, 250 Palestinian firms are working in the information and communication technology sector, generating about 6.1 percent of Palestinian economic activity in 2011. Although the numbers are skewed by the outsized influence of local telecom PalTel, the tech sector nonetheless is now larger than the agriculture sector, which historically has been a mainstay of the local economy.

The Palestinians face some tough competition.

Neighboring Jordan has developed into one of the leading information and communications technology sectors in the region, with more than 400 active companies that directly employ about 16,000 employees and overall contribute about 84,000 jobs to the economy.

According to the Information Technology Association of Jordan, the information and communications technology sector is the third-largest contributor to the kingdom's economy, making up 14 percent of economic activity. Cisco Systems Inc., Microsoft Corp., Oracle Corp. and Intel Corp. are some of the tech giants that have invested in Jordan.

For now, some 40 percent of Palestinian technology companies are engaged in outsourcing and receive work from the U.S., European firms and Israel, according to the Palestinian Information Technology Association. Some workers have Silicon Valley experience and bring back a wealth of ideas and experience.

Undeterred by barriers, association chairman Hassan Kassem said: "You can be part of any team and do it remotely from here."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-04-17-Palestinians-Startup%20Nation/id-54b7010ee5404c92891d4d254be07305

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Star Trek Into Darkness Trailer: Go Beyond the Darkness!

Source: http://www.thehollywoodgossip.com/2013/04/star-trek-into-darkness-trailer-go-beyond-the-darkness/

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Wednesday, April 17, 2013

Government 's clumsy effort to appease sex-education lobby ...

SPUC has criticised comments about sex education by Elizabeth Truss, the education and childcare minister. Mrs Truss said in a letter published in The Times yesterday (15 April) that just as much sex education will be included in the new National Curriculum for England.? A draft new curriculum has been issued for consultation, which closes today. The Government's clumsy effort to appease the sex-education lobby threatens parental rights.

Responding to Mrs Truss, Antonia Tully of the SPUC?s Safe at School campaign told the media:

?Mrs Truss has prejudged the outcome of the consultation which only closes today. The National Curriculum for science contains no reference to sex and relationships, but only to ?reproduction? - including plants and animals.

?Sex education is not currently part of the mandatory science curriculum and is included only in the non-statutory suggestions for PSHE lessons. A consultation exercise about the National Curriculum has been in progress since February."

In a submission to the consultation (full text) SPUC Safe at School points out that references to 'reproduction' in the science curriculum are being abused. Explicit sex-education resources are being used in mandatory science lessons for primary school children. In some cases, resources have simply been transferred to science periods to thwart parents' rights to object to what some have called 'kiddie-porn'. Parents are entitled to withdraw children from sex lessons, but schools can force parents to submit their children to attend science classes.?

Antonia continued:

?Sex education lessons are required to be appropriate to the age and cultural background of the children, but this requirement does not apply to what children are shown in science lessons.?

We believe the curriculum should make clear that it does not permit discussing explicit sexual matters with primary school children at Key Stages 1 and 2. In some ways, the draft new curriculum is an improvement on the current curriculum. It will no longer be possible for teachers to interpret the science curriculum at Key Stage 1 to include sex organs when teaching 5-6 year olds about basic body parts. However, the Year 5 programme of study requires children to describe reproduction in a variety of animals, and humans are included. This means that children aged 9-10 years may be subjected to graphic sex education from which their parents are powerless to withdraw them.

There is no evidence that teaching primary age children about sex improves their sexual health as they grow up."

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Source: http://spuc-director.blogspot.com/2013/04/government-s-clumsy-effort-to-appease.html

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Newtown parents back study for clues to violence

HARTFORD, Conn. (AP) ? As parents, Jeremy Richman and Jennifer Hensel were plunged into grief when their only child, 6-year-old Avielle, was killed in the massacre at Sandy Hook Elementary School. As scientists, they wanted answers about what could lead a person to commit such violence.

The couple believes it's unlikely there ever will be a full answer explaining why a man gunned down 26 people inside the Newtown, Conn., school last year. But they feel more research into brain health ? and how a propensity for violence is manifested ? could help prevent future tragedies.

"When we started reaching out to scientists to talk about the underpinnings of violence and how this particular factor played a role in what happened to us, there is some, but no real, research going on this field," Hensel said.

On Monday, they announced a scientific advisory board for the Avielle Foundation, which was established with the goal of reducing violence. While some other victims' families have immersed themselves in the push for tighter gun restrictions, Avielle Richman's parents see the foundation named for their curly-haired daughter as their response to a tragedy that has launched advocacy work on many fronts, including school safety and mental illness.

The Dec. 14 massacre was carried out by 20-year-old Adam Lanza, who killed 20 first-graders and six educators inside the school with a military-style semi-automatic rifle before committing suicide. The isolated, socially awkward Lanza played first-person shooter video games in a weapon-filled house where he lived with his mother, according to search warrants released last month, but authorities have not described a possible motive or released details of any medical condition that might shed light on his actions.

Avielle, a girl who loved horses, Harry Potter and the color red, had moved to Connecticut with her family about two years before the shooting. Her father kept a blog called "Avielle's Adventures," telling friends about a trip to a Thanksgiving Day parade, her 6th birthday at a horse stable, a road trip to Iowa.

Jeremy Richman is a researcher at the pharmaceutical company Boehringer Ingelheim. Hensel, his wife, is a medical writer with her own company. The foundation is a way for them to harness their training and skills ? and to channel their grief.

"I think the best way to help from a tragedy such as this is by action where your strengths lie," Hensel said. "This is our motivation now. We will never stop being parents to Avielle."

The Avielle foundation, funded through donations and grants, aims to raise $5 million this year and begin reviewing its first grant applications later this year.

One member of the foundation's advisory board, Terrie E. Moffitt, said science on the origins of violence has been neglected by federal agencies that provide research grants.

"Families of individuals with autism, ADHD, learning problems or schizophrenia demand that funding agencies support research into these disorders," said Moffitt, a neuroscience professor at Duke University and at the Institute of Psychiatry, King's College London. "Families of violent individuals don't."

The other members of the board announced Monday are R. John Krystal, chair of the psychiatry department at the Yale University School of Medicine, and James Blair, chief of the unit on affective cognitive neuroscience at the National Institute of Mental Health.

The Avielle Foundation says it hopes to remove stigmas for people seeking mental health aid, develop the concept of a "brain health check-up," and identify behavioral and biochemical diagnostics for detection of people at risk of violent behaviors.

Source: http://news.yahoo.com/newtown-parents-back-study-clues-violence-141133354.html

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Tuesday, April 16, 2013

Brotherhood members face torture charge in Egypt

CAIRO (AP) ? Two Muslim Brotherhood officials have been sent to trial on charges of kidnapping and torturing three men during protests in November following Islamist President Mohammed Morsi's decrees, since rescinded, that granted him near absolute powers.

The case in the Nile Delta city of Damanhour north of Cairo is the first of its kind against Morsi's Brotherhood and is likely to embarrass the group at a time it is trying to fend off opposition charges of monopolizing power in the deeply polarized country.

Mohammed Bahnasy, a lawyer for the three victims, told The Associated Press on Sunday that the case was referred to trial a day earlier. The two Brotherhood local officials ? Mustafa el-Khouli and Mohammed Abdel-Radi ? have not been detained.

An arrest warrant has been issued for el-Khouli, who has failed to respond to a summons for questioning, according to Bahnasy. Abdel-Radi was questioned and released pending the start of the trial, according to him and another lawyer involved in the case, Mohammed Abdel-Aziz.

The Brotherhood's chief lawyer, Abdel-Monaim Abdel-Maqsoud, said the decision to refer the two to trial was "hurried" and described the investigation as "flawed."

He told the AP defense witnesses showed up at the prosecutors' office on Saturday to testify that el-Khouli and Abdel-Radi were innocent, only to be told it was too late.

"Everything will now have to wait for the trial," he said. "I am surprised at the speed with which this has been done. We have many cases of Brotherhood victims of violence and we have not seen any of them go to trial yet," said Abdel-Maqsoud.

He confirmed that the case against the two was the first of its kind since the ouster two years ago of autocrat Hosni Mubarak.

Bahnasy said the three men allegedly kidnapped and tortured were Mahmoud Ali, 17, Mohammed Mansour, 18, and Mustafa Farag, 21. He said the three were detained separately for up to five hours during clashes between supporters and opponents of Morsi at Damanhour's main square on Nov. 24.

El-Khouli was identified by Bahnasy and Abdel-Aziz as the administrative head of the Brotherhood's office in Damanhour. They said Abdel-Radi is a senior member of the local branch of the Brotherhood's Freedom and Justice Party.

The two were sent to court following a two-day sit-in by the three victims and their supporters outside Damanhour's prosecution office to protest against what they claimed was stalling on a trial.

The Damanhour case is just one of a series of bouts of political violence in the turmoil roiling Egypt since the overthrow of Mubarak's regime in February 2011.

The violence has deepened the political schism tearing Egypt apart since Morsi took office nine months ago as the country's first ever freely elected president.

At least a dozen offices belonging to the Brotherhood and its Freedom and Justice Party were ransacked, some torched, by protesters angered by Morsi's decrees.

The decrees gave immunity from the courts to an Islamist-dominated panel that drafted and hurriedly adopted a new constitution. The document was later ratified in a nationwide referendum.

One major bout of violence was on Dec. 5 when Morsi supporters were shown on video posted on social networking sites to be running impromptu detention centers outside the presidential palace in Cairo, where they tortured protesters during daylong clashes in the area.

The Brotherhood says at least 10 of its supporters were killed that day, but the opposition disputes the figure and maintains that Morsi supporters started the violence when they set upon peaceful protesters staging a sit-in outside the palace.

On March 22, the two sides clashed outside the Brotherhood's national headquarters in an eastern Cairo district. Both sides, according to witnesses, detained and beat members of the rival side during daylong clashes with rocks, sticks and firebombs.

The violence that day had its roots in an incident a week earlier when Brotherhood supporters assaulted a small crowd of protesters painting anti-Morsi graffiti on the street outside the Brotherhood's headquarters. One Brotherhood supporter was caught on camera slapping a female protester to the ground.

The Brotherhood maintains that its supporters were provoked and that they had pleaded with the activists not to paint abusive graffiti or plaster flyers on the headquarters' walls.

Morsi blames thugs for the political violence and accuses the opposition of providing political cover for it. The opposition, mostly liberal and secular, maintains that it does not condone violence.

Bahnasy said the referral documents leave no room for doubt that the alleged detention and torture of the three men took place in the Brotherhood's Damanhour offices and quotes witnesses as saying they had seen sticks, tasers and swords inside the group's headquarters.

"I will study every relevant legal book to prepare for this case," said Bahnasy, a native of Damanhour. "I will do nothing but this case and I will pursue it to the very end."

Mahmoud Duweir, a Damanhour activist, said he was at the city's main square when the Nov. 24 incident took place.

"All three came out with their clothes ripped. They had bruises and marks of blows from sticks on their bodies."

A Brotherhood supporter, Islam Massoud, was killed in clashes in the square a day later in a case that has been intensely publicized by the group.

The Brotherhood says he was killed by opposition protesters. But Bahnasy, Abdel-Aziz and Duweir insist he was slain by a single blow to the head by a Brotherhood supporter who mistook him for a protester during pitched street battles.

Source: http://news.yahoo.com/brotherhood-members-face-torture-charge-egypt-201912327.html

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Mecum Kicks Off Spring With $25 Million Auction In Houston ...

Walworth, Wis. ? It was not a quiet weekend for Houston?s Reliant Center as Mecum Auctions brought the sounds of revving engines and falling hammers echoing through the venue packed with collector vehicles and car enthusiasts from across the nation. The three-day auction held April 4-6 saw 1,034 cars cross the block and nearly 200 pieces of Road Art and memorabilia. With a sell-through rate of 72 percent, auction sales reached a $25,062,931 total.

The cars were the stars filling the Reliant Center to capacity with an incredible ?something for everyone? mix of muscle cars, classics, hot rods and more. Discovery?s Velocity Network broadcast the auction action live all three days as a total of 740 cars exchanged hands.

Hammering at $220,000 and garnering the top sale was a 1970 Ford Mustang Boss 429 Fastback (Lot S134) with its original drivetrain and interior. The local-to-Texas restoration is a low-mile and extensively documented example of its breed, one of only 499 built and a one-owner vehicle for the past 20 years ? all coveted features that helped drive the desirability of this already revered muscle car. Bringing a $185,000 sale and grabbing the second seat on the top 10 sales list was an extremely rare-production Cadillac, a 1931 V-12 Roadster (Lot S159.1) complete with accessory trunk and rumble seat complementing its distinguished vintage flair.

The complete top 10 sales for Mecum?s second annual Houston auction include (all sales reflect hammer prices):

1. 1970 Ford Mustang Boss 429 Fastback (Lot S134) at $220,000
2. 1931 Cadillac V-12 Roadster (Lot S159.1) at $185,000
3. 1954 Buick Skylark (Lot S130) at $140,000
4. 1959 Chevrolet Corvette Resto Mod (Lot S227) at $135,000
5. 2009 Dodge Challenger (Lot S258) at $130,000
6. 1967 Chevrolet Corvette Coupe (Lot F190) at $125,000
7. 1972 Chevrolet Camaro RS/SS (Lot S254) at $125,000
8. 1963 Chevrolet Corvette Split Window Coupe (Lot F233) at $122,000
9. 1958 Chevrolet Corvette Convertible (Lot F203) at $107,500
10. 1970 Plymouth Superbird (Lot S251) at $107,000

For access to complete auction results and other member benefits, sign up for the free InfoNet service offered at www.Mecum.com.

Not only was Houston a marked success, but Mecum proved once again that two auctions in one weekend isn?t too much for the world leader in collector car and Road Art sales. As more than 1,000 cars crossed the block in Houston, nearly 200 tractors simultaneously went under the hammer at the Spring Gone Farmin? Vintage Tractor Auction in Davenport, Iowa, April 5-6 achieving an astonishing 98 percent sell-through rate. Full results for the tractor auction are also available via the Mecum InfoNet.

The gavel never rests for long in Mecum hands and in just weeks the next event will be held in Kansas City, Mo., April 25-27 followed by Dana Mecum?s 26th Original Spring Classic this May 14-19 in Indianapolis. To consign a vehicle or to pre-register to bid at one of Mecum Auctions? upcoming events, visit www.Mecum.com or call (262) 275-5050.

About Mecum Auctions

Nobody sells more than Mecum. Nobody. The Mecum Auction Company is the world leader of collector car and Road Art sales, hosting auctions throughout the United States. The company has been specializing in the sale of collector cars for 26 years, now offering more than 15,000 vehicles per year and averaging more than one auction each month. Established by President Dana Mecum in 1988, Mecum Auctions remains a family-run company headquartered in Walworth, Wis. For further information, visit www.mecum.com or call (262) 275-5050. Follow along with Mecum?s social media news and join us on Facebook, Twitter, YouTube, Pinterest and Instagram.

Source: Mecum Auctions

? Photos: 2014 Chevrolet Camaro SS | Home | Auctions America Announces Exciting List of Attractions for its Auburn Spring Collector Car Weekend ?

Source: http://www.victorymusclecars.com/?p=11178

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Monday, April 15, 2013

Skin cells turned directly into the cells that insulate neurons

Apr. 15, 2013 ? Researchers at the Stanford University School of Medicine have succeeded in transforming skin cells directly into oligodendrocyte precursor cells, the cells that wrap nerve cells in the insulating myelin sheaths that help nerve signals propagate.

The current research was done in mice and rats. If the approach also works with human cells, it could eventually lead to cell therapies for diseases like inherited leukodystrophies -- disorders of the brain's white matter -- and multiple sclerosis, as well as spinal cord injuries. The study will be published online April 14 in Nature Biotechnology.

Without myelin to insulate neurons, signals sent down nerve cell axons quickly lose power. Diseases that attack myelin, such as multiple sclerosis, result in nerve signals that are not as efficient and cannot travel as far as they should. Myelin disorders can affect nerve signal transmission in the brain and spinal cord, leading to cognitive, motor and sensory problems.

Previous research in rodent disease models has shown that transplanted oligodendrocyte precursor cells derived from embryonic stem cells and from human fetal brain tissue can successfully create myelin sheaths around nerve cells, sometimes leading to dramatic improvements in symptoms. "Unfortunately, the availability of human fetal tissue is extremely limited, and the creation of OPCs from embryonic stem cells is slow and tedious," said the study's senior author, Marius Wernig, MD, assistant professor of pathology and a member of Stanford's Institute for Stem Cell Biology and Regenerative Medicine. "It appeared we wouldn't be able to create enough human OPCs for widespread therapeutic use, so we began to wonder if we could create them directly from skin cells."

Nan Yang, PhD, a postdoctoral scholar in the Wernig laboratory and lead author of the study, pointed out that there is another advantage to using this technique. "By using the patient's own skin cells, we should be able to generate transplantable OPCs that are genetically identical to the patient's natural OPCs," Yang said. "This allows us to avoid the problem of immune rejection, which is a major complication in transplantation medicine."

Last year, Wernig's team successfully created human nerve cells out of skin cells. Other researchers had successfully used a similar process to turn skin cells into embryonic-like cells called induced pluripotent stem cells, and then grow those iPS cells into nerve cells, but Wernig's lab was the first to convert skin cells directly into nerve cells without the intermediate iPS cell step.

The team's current research project also involved directly converting skin cells into OPCs without having to create iPS cells. The researchers showed that mouse and rat skin cells could be directly converted into OPCs, and that these cells would successfully myelinate nerve cells when transplanted into the brains of mice with a myelin disorder.

Next, the team plans to reproduce the research in human cells; if successful, the approach could lay the groundwork for therapies for a wide array of myelin disorders and spinal cord injury.

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The above story is reprinted from materials provided by Stanford University Medical Center. The original article was written by Christopher Vaughan.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Nan Yang, J Bradley Zuchero, Henrik Ahlenius, Samuele Marro, Yi Han Ng, Thomas Vierbuchen, John S Hawkins, Richard Geissler, Ben A Barres, Marius Wernig. Generation of oligodendroglial cells by direct lineage conversion. Nature Biotechnology, 2013; DOI: 10.1038/nbt.2564

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/c6P1AiDhxCc/130415124807.htm

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Sunday, April 14, 2013

Frank H. Wu: The Pipeline into the Legal Profession

The current challenges to legal education are a result of the profound changes in the legal marketplace. They have not arisen in isolation. The problem is the pipeline into the profession. The traditional progression from student to associate to partner is no longer optimal for the client who is being served.

The expectations for the education of new lawyers are increasing, but the willingness to pay for the process is decreasing. The issue is who will pay for much-needed training. Either before the bar exam or shortly thereafter, a lawyer must learn basics such as how to draft a complaint and a contract, how to interview a witness, what a financial statement indicates, etc. Preferably well before matriculating in law school -- though this cannot be counted on -- she should know how to write competently in standard English.

Almost all of the responsibility for book learning has been accepted by schools. That's not the issue. It's the development of practical skills that's at dispute. More to the point, it's the price of that education that has become contentious.

The tab could be picked up by any of the following in combination: the clients, the firms, the students, or the public. The issues of who will impart the skills and how best to do it are not trivial, but it is the costs which are most controversial.

Clients with market power say emphatically that they will not pay for associates to learn the requisite skills.

The big firms historically had passed on the costs, in a manner that distributed them. A new associate was not worth her billing rate at the outset, but her time was tucked away on an invoice that would be paid because if you wanted a high-end firm doing your work then that was the cost.

The small firms and mid-size firms, which are much more the norm than the big firms, may have had less formal orientation programs but they have more side-by-side collegiality. They absorbed the cost themselves, in the form of lower compensation all around for partners and associates.

As firms of all types try to assign this instructional role to schools, the schools typically pass the burden on to the students. Thus the cost of the clinic is covered by an increase in tuition.

The alternative of public support likely will not appeal to the taxpayer. The government, however, could do more through robust state appropriations for the educational system, direct subsidies for post-graduate public service, or a Gideon right-to-counsel in civil cases that would create jobs.

To start addressing the problem, it is necessary to identify it. Here is an effort at a neutral description. We have a series of vicious cycles that interlock and ratchet.

Law firms have become much more business-like. They have raised their billing rates as high as they can.

Clients have balked. They too are more savvy. Corporations have their own general counsel who has come from a law firm and knows its tricks. As the most senior partners charge more, in-house counsel have responded by agreeing to pay on the condition they actually receive the benefit of that specific person's expertise. The senior partners can command their rate of more than a thousand dollars per hour, but only by foregoing the the revenue of a half-dozen associates supporting them.

Law firms also have a new model. The pyramid structure is no longer stable. That system, with large numbers of associates being winnowed out to leave a few who would make partner at the seven year mark, was always a Ponzi scheme -- except there was no fraud because the arrangement is disclosed.

Law firms are trying different configurations. They have contract attorneys and others who will never own equity in the business. These individuals receive a level of training appropriate for their roles, but they don't expect the genuine mentoring that would be given to someone who will become an owner of the company.

Culture has evolved as well. Since Curt Flood challenged the feudal system of major league baseball two generations ago, every professional has become a "free agent." The most ambitious associates are smart enough to see their opportunities will be constrained if they remain in place for too long. Their very human reaction to the lack of loyalty shown to them as employees is to reciprocate, by becoming less loyal to employers in turn.

The most elite firms have a remedy. It is the recruitment of already experienced attorneys, in preference to new graduates.

But this approach only works for the firms at the top of the market and it will be effective only until the supply runs out. Somebody has to hire new lawyers to ensure we have experienced lawyers. Eventually, thanks to the increasingly restricted access to the court system, there won't be many lawyers with real trial experience.

The more firms compete to attract laterals through compensation, the more internally stratified they become. The more stratified they become, the less they invest in growing their own juniors. And so on.

Finally, the preparation to be a lawyer is more difficult because the law is more complex. Fifty years ago, there were fewer statutes, regulations, and cases. A lawyer litigating a dispute did not worry about investigating email and social media. A lawyer drafting a contract gave no thought to whether it would be enforceable in China.

We collectively have become dependent on circumstances that will not last much longer. The crisis for legal education is a portent.

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Source: http://www.huffingtonpost.com/frank-h-wu/the-pipeline-into-the-leg_b_3077480.html

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Analysis: Beijing to US on North Korea _ talk

BEIJING (AP) ? Embedded within Chinese leaders' convoluted, yet vague statements to Washington about North Korea is a simple message: Talk with Pyongyang.

U.S. Secretary of State John Kerry's weekend discussions with officials in Beijing offered up the usual encouraging but familiarly noncommittal language on North Korea, emphasizing Beijing's desire to strike a balance between easing tensions on the Korean Peninsula while not appearing to side against its prickly communist ally Pyongyang.

But while neither side offered details of their exchanges, Beijing is communicating its strong desire for some form of direct contact between the U.S. and North Korea as a means of defusing the ongoing crisis over North Korea's nuclear threats that have prompted a massive show of force by the U.S. and South Korea.

"North Korea wants to talk, so why not talk?" said Shen Dingli, a regional security expert and director of the Center for American Studies at Shanghai's Fudan University. The question for China, Shen said, is how to make such discussions come about, adding that China is unlikely to make such calls too explicit for fear of putting either side in an embarrassing quandary.

Highlighting the difficulties of getting North Korea to talk with the U.S., the North rebuffed last week's proposal by Seoul to resolve the tensions through dialogue. North Korea dismissed the proposal as a "crafty trick" to disguise what Pyongyang calls the South's hostility, and said it won't talk unless Seoul abandons its confrontational posture.

Chinese media reports on Kerry's Saturday talks largely downplayed North Korea, and the Foreign Ministry's official statements were predictably blurry. In its account of his meeting with Kerry, the ministry quoted Premier Li Keqiang as referring only to "those who stir up trouble on the peninsula only harm their own interests, like moving a stone only to drop it on one's own foot."

That was a near echo of President Xi Jinping's own comment in a speech earlier this month that "no one should be allowed to throw the region, or even the whole world, into chaos for selfish gains" ? seen as much as a rebuke to the U.S. and its allies as to North Korea's young leader, Kim Jong Un. The ministry's account of Kerry's meeting with Xi didn't mention the Korean Peninsula even obliquely.

While China has grown more critical of North Korea since the latter's third nuclear test in February, Beijing remains highly wary of pushing the hardline communist regime too far. China says it wants a Korean Peninsula free from nuclear weapons, but that all sides must play a role in that.

The stakes are high for China, with a potential conflict threatening its economic development and stability in the northeast along its long, meandering border with North Korea. Beijing abhors the prospect of a pro-U.S. unified Korean state on its border as well as internal North Korean conflict that could spark an outflow of refugees.

China was already displeased by Kim's lack of outreach and lack of concern for Beijing's interests, and signed on to tighter U.N. sanctions following the North's latest nuclear test in February. It's also stepped up customs checks along their border, slowed some deliveries of equipment to the North and cracked down on suspect financial transactions by North Korean banks.

That's had little apparent effect on Kim's behavior, and he seems emboldened by China's lack of a forceful response to past crises and Pyongyang's perceptions of China's fear of a collapse of the regime. While North Korea's population is starving and impoverished, the leadership gets by on Chinese food and fuel, along with growing investment, and imports of North Korean iron ore and other raw materials.

Despite that, it's not clear what, if any, further pressure China is willing to exert, and if Xi, Li or others offered any further commitments, neither side was saying.

"Theoretically, there is more that China can do, but we're very worried that doing so could stimulate Kim to do even more dangerous things," said Shi Yinhong, an international relations expert at Renmin University in Beijing.

"Be prudent, don't go too far" is China's message to Washington and South Korea, Shi said.

While direct Washington-Pyongyang communication may offer a start, the ultimate key to easing tensions long-term lies in involving the other regional players, said Zhang Liangui, a researcher with the ruling Communist Party's main research and training institute in Beijing.

That would mark a return to Beijing's preferred format of six-nation talks involving the two Koreas, China, the U.S., Japan and Russia, a process stalemated since 2009 over how to ensure North Korean compliance with denuclearization measures. Chinese Foreign Minister Wang Yi again communicated Beijing's preference for the Chinese-hosted talks in his Saturday meeting with Kerry.

"This is not an issue for the two sides only," said Zhang, who is close to the Chinese leadership but said he had no direct knowledge of Kerry's meetings. "It concerns the entire region, so all the countries involved should take part."

China is not the only one suggesting a phone conversation between the sides. Flamboyant former NBA player Dennis Rodman made the same point following a bizarre trip to Pyongyang and meetings with Kim in March.

Both Kim and President Barack Obama love basketball "and there is even more they could talk about if Obama would just pick up the phone and call him," Rodman said following the trip.

Source: http://news.yahoo.com/analysis-beijing-us-north-korea-talk-090502853.html

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